Toxicity of <i>Hypericum perforatum</i>

MANIFESTATIONS OF TOXICITY Organ Toxicity

The discipline of toxicology considers the adverse effects of chemicals, including drugs, and other agents, such as biological toxins and radiation, on biological systems. Toxicity associated with drug action can generally be characterized as either an extension of the therapeutic effect, such as the fatal central nervous system (CNS) depression that may follow a barbiturate overdose, or as an ...

Electrocardiographic Manifestations of Benzodiazepine Toxicity

Background: The aim of this study was to evaluate and compare the clinical and ‎electrocardiographic (ECG) manifestations of benzodiazepines (BZs).‎ Methods: In this retrospective study, all BZ-poisoned patients hospitalized at Loghman ‎Hakim Hospital between September 2010 and March 2011 were evaluated. Patients’ ‎information including age, sex, time elapsed between the ingestion and presenta...

Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments

Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effect...

A Heart-Wrenching Case of Loperamide Toxicity

ATTENUATION OF PARAQUAT TOXICITY IN MICE

Paraquat (PQ) is a widely used herbicide. However, a large number of cases of accidental or suicidal poisoning from PQ has been reported. Membrane damage induced by lipid peroxidation, inactivation of protein or damage to DNA by radical formation have been suggested as toxicity mechanisms of PQ. In the present work, the effects of atropine, propranolol, procainamide and dipyridamole on PQ-...